For three-and-a-half years, Sana Siddiqui (28) and her husband Amaan Siddiqui (31) lived with unanswered questions and repeated treatment setbacks. Despite seeking fertility care earlier, they were unable to achieve a pregnancy and were emotionally exhausted after two unsuccessful IUI attempts using donor sperm at another centre.
When they arrived at Birla Fertility & IVF, Ahmedabad, their journey began with a deeper and more comprehensive evaluation. Sana was diagnosed with poor ovarian reserve, a condition in which the ovaries produce fewer eggs than expected for age. With an AMH of 0.4 ng/mL and a low antral follicle count, it was clear that every egg retrieved would be important for the treatment plan.
Amaan’s evaluation revealed a different but equally challenging diagnosis. Two semen analyses showed no sperm, while his normal hormone levels suggested obstructive azoospermia. This condition occurs when sperm production is present, but a blockage prevents sperm from entering the semen. Identifying this distinction was critical, as it meant viable sperm could still be retrieved directly from the testes.
Under the care of Dr. Nimisha Shantilal Pandya, a personalised IVF-ICSI plan was developed, keeping both medical complexity and emotional wellbeing in mind. Surgical sperm retrieval through TESA was performed, and the retrieved sperm was cryopreserved. This helped the team avoid repeated procedures and plan treatment across cycles, an important consideration given Sana’s limited ovarian reserve.
A multi-cycle IVF approach was adopted to strengthen the overall treatment outcome. Ovarian stimulation was carefully planned, embryos were cultured under close embryology oversight, and frozen embryo transfers were timed to support implantation.
The moment the beta hCG test returned positive marked a turning point in a long journey of uncertainty.
Today, Sana and Amaan are parents to healthy twin baby girls. Their case reflects how thoughtful diagnosis, coordinated clinical and embryology care, and a step-by-step treatment approach can help address even complex dual-factor infertility cases.
Note: Patient names have been changed to protect privacy.
